Status:
UNKNOWN
Study of Specific Viral Immune Responses Induced by SARS-CoV-2 (COVID-19)
Lead Sponsor:
Centre Hospitalier Universitaire de Besancon
Conditions:
SARS-CoV-2 Infection
Eligibility:
All Genders
18+ years
Brief Summary
SARS-CoV-2, has caused an international outbreak of respiratory illness termed Covid-19. The investigators used peptides derived from SARS-CoV-2 virus, to study viral-specific immune responses. COV-CR...
Eligibility Criteria
Inclusion
- COVID-19 PCR positive,
- Hospitalized patients with illness of any duration, and/or SpO2 ≤ 92% on room air.
- Cohorte C : patients with cancer (hematological malignancies and solid tumors).
Exclusion
- Refusal to participate,
- Any immunosuppressive therapy (i.e. corticosteroids \>10mg of hydrocortisone or equivalent dose) within 14 days before the planned start of study,
- Active or chronic hepatitis B or C and/or HIV positive (HIV 1/2 antibodies patients), or a known history of active Tuberculosis bacillus,
- Active autoimmune disease that required a systemic treatment, with the following exceptions:
- Patients with a history of autoimmune-related hypothyroidism who are on thyroid replacement hormone are eligible for the study,
- Patients with controlled Type 1 diabetes mellitus who are on an insulin regimen are eligible for the study,
- Prior allogeneic bone marrow transplantation or prior solid organ transplantation,
- Patients currently exposed to chemotherapy, anti-tumor immunotherapy as anti-PD-1, anti-PD-L1, or anti-CTLA4 agent or any immune therapy or biotherapy (except for patients in cohort C),
- Previous prescribing of biotherapy or treatment for the management of COVID-19 is not an exclusion criterion,
- Patient under guardianship, curatorship or under the protection of justice.
Key Trial Info
Start Date :
April 20 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 20 2025
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT04365322
Start Date
April 20 2020
End Date
April 20 2025
Last Update
July 14 2020
Active Locations (1)
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1
CHU Jean Minjoz
Besançon, France, 25030