Status:
COMPLETED
Cardiovascular Effects of COVID-19
Lead Sponsor:
NYU Langone Health
Conditions:
COVID-19
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Cardiometabolic disease may confer increased risk of adverse outcomes in COVID-19 patients by activation of the aldose reductase pathway, a trigger of the inflammatory cascade. The study team hypothes...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Registry Study: In order to be eligible to participate in the registry study, an individual must meet all of the following criteria:
- Age ≥18 years of age
- Hospitalized at one of the participating NYULH locations
- Confirmed COVID-19 infection
- Interventional Study: In order to be eligible to participate in the registry study, and individual must meet all of the inclusion criteria of the registry study plus the following criteria:
- Hospitalized at NYU Tisch
- History of diabetes mellitus or blood glucose measurement \>126 mg/dl AND EITHER
- History of hypertension and/or ischemic heart disease and/or heart failure OR
- Other co-morbid condition that in the opinion of the PI increases risk of heart or lung injury related to the aldose reductase pathway
- Exclusion Criteria
- Registry Study: An individual who meets any of the following criteria will be excluded from participation in the registry study:
- Persons who have opted out of research participation at NYU
- Pregnancy
- Interventional study: An individual who meets any of the following criteria will be excluded from participation in the interventional study:
- Persons who have opted out of research participation at NYU
- Pregnancy
- Women of childbearing potential
- Breast-feeding women
- Participation in another investigational drug protocol within previous 30 days
Exclusion
Key Trial Info
Start Date :
April 8 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2021
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT04365699
Start Date
April 8 2020
End Date
January 31 2021
Last Update
September 16 2021
Active Locations (1)
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1
NYU Langone Health
New York, New York, United States, 10016