Status:
COMPLETED
Study of the Pathogenesis of Olfactory Disorders in COVID-19
Lead Sponsor:
Institut Pasteur
Collaborating Sponsors:
Hôpital Lariboisière, AP-HP
Conditions:
Coronavirus Infection
Severe Acute Respiratory Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
This study is a case-control study to characterize the molecular and cellular anomalies of the olfactory epithelium of COVID-19 patients with isolated anosmia, by comparison with the olfactory epithel...
Detailed Description
Olfactory and taste dysfunctions are common and early onset in COVID-19, especially in pauci symptomatic patients, and may be the main clinical manifestations of the infection. Olfactory dysfunction c...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- COVID-19 patients
- Age \> 18 years
- Subject consulting in the context of the COVID-19 screening care for a suspected SARS-CoV-2 infection
- Controls
- Age \> 18 years
- Subject consulting in the ear, nose and throat department with no biologically confirmed COVID-19 or suspected COVID-19 in the past 8 weeks, and no symptoms suggestive of COVID-19 or another respiratory disease and therefore no recent anosmia or ageusia
- Exclusion Criteria (both COVID-19 patients and controls):
- Refusal or contraindication to nasal swab
- Presence of nasal sinus pathology
Exclusion
Key Trial Info
Start Date :
May 4 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 29 2020
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04366934
Start Date
May 4 2020
End Date
October 29 2020
Last Update
September 22 2025
Active Locations (2)
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1
Hôpital Lariboisière, Policlinique
Paris, France
2
Hôpital Lariboisière, Service ORL
Paris, France