Status:
COMPLETED
Effect of Pentoxifylline on Endothelial Dysfunction in Patients With Acute Coronary Syndrome
Lead Sponsor:
Ain Shams University
Conditions:
Acute Coronary Syndrome
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
PHASE3
Brief Summary
This study aims to investigate the effect of pentoxifylline administration on the status of endothelial function and oxidative stress biomarkers in patients with Acute Coronary Syndrome (ACS).
Detailed Description
The study will be carried out at Ain Shams University Hospitals. Patients with ACS who meet the eligibility criteria and consent to participate in the study will be randomly allocated to either the in...
Eligibility Criteria
Inclusion
- Patients aged 18-80 years old.
- Recent ACS diagnosed-patients within the past 2 weeks.
Exclusion
- Known allergy to pentoxifylline
- Heart failure New York Heart Association (NYHA) class III or IV
- Severe Left Ventricular Dysfunction (left ventricular ejection fraction \<30%)
- High Serum creatinine level ≥ 2 mg/dl
- Liver disease (baseline alanine transaminase \>2.5 times the upper limit of normal)
- Active bleeding or bleeding diathesis
- Major surgery or trauma within 1 month
- Recent cerebral and/or retinal hemorrhage within 3 months
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 25 2022
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT04367935
Start Date
January 1 2021
End Date
April 25 2022
Last Update
September 7 2022
Active Locations (1)
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1
Ain Shams University Hospitals
Cairo, Egypt, 11588