Status:
COMPLETED
Combined Sensitivity and Specificity of Cortical Lesions and Central Vein Sign for MS Diagnosis and Differential Diagnosis
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Multiple Sclerosis)
Eligibility:
All Genders
Brief Summary
This study investigates the specificity/sensitivity of the combined presence of cortical lesions (CLs)/leuco-cortical lesions (LCLs) and central veins sign (CVs) for multiple sclerosis (MS) diagnosis ...
Detailed Description
CLs and LCLs may be detected at 3 Tesla (T) MRI by using dedicated sequences. 3D Double inversion recovery (DIR), Phase-Sensitive Inversion Recovery (PSIR), Magnetization Prepared - RApid Gradient Ech...
Eligibility Criteria
Inclusion
- Clinical and MRI data of patients with MS or MS mimics (migraine, vasculitis, diabetes, neuromyelitis optica spectrum disorder)
- MRI data must have been collected at 3T between 1990 and 2020 and must include T1 w, T2 w, T2-star based sequence (CVs detection) and DIR/PSIR/MP2RAGE (eventually also high spatial resolution MPRAGE) for cortical lesion detection
Exclusion
- Unavailability of institutional informed consent
- Unclear diagnosis
- Other neurological or psychiatric diseases.
Key Trial Info
Start Date :
June 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2023
Estimated Enrollment :
1051 Patients enrolled
Trial Details
Trial ID
NCT04369898
Start Date
June 1 2010
End Date
September 1 2023
Last Update
January 22 2024
Active Locations (1)
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1
Translational Imaging in Neurology, University Hospital Basel
Basel, Switzerland, 4031