Status:
WITHDRAWN
Prospective Investigation of Oxidative Stress in West Nile Virus Infection
Lead Sponsor:
Institute of Tropical Medicine, Belgium
Collaborating Sponsors:
Victor Babes Hospital, Bucharest, Romania
Universiteit Antwerpen
Conditions:
West Nile Virus
West Nile Fever
Eligibility:
All Genders
18+ years
Brief Summary
The investigator hypothesizes that oxidative stress responses to West Nile virus infection in the central nervous system determine the severity of infection and the long-term neurological, neuropsycho...
Eligibility Criteria
Inclusion
- Willing and able to provide written informed consent. If the clinical condition of the patient does not permit giving consent, informed consent will be obtained from the next of kin.
- Age 18 years or older
- for active cases: positive anti-WNV IGM antibodies in serum (or IgG in CSF if applicable)
- for active cases: presentation within (maximum) 7days of symptom onset
- for healthy controls: anti-WNV antibody naive (IgM and IgG in serum). The group of healthy controls will be selected to have an age similar distribution to the cases.
Exclusion
- Evidence of active systemic infection in 3 months prior to recruitment
- Evidence of systemic inflammatory illness
- Clinical signs of neurodegenerative or neurologic disease other than WNND
- Pregnancy
- Active malignancy
- History of drug abuse
Key Trial Info
Start Date :
September 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2023
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04371003
Start Date
September 1 2020
End Date
December 31 2023
Last Update
February 10 2021
Active Locations (1)
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1
Victor Babes Hospital
Bucharest, Romania