Status:
COMPLETED
Pulmonary and Ventilatory Effects of Bed Verticalization in Patients With Acute Respiratory Distress Syndrome
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Acute respiratory distress syndrome (ARDS) is defined using the clinical criteria of bilateral pulmonary opacities on a chest radiograph, arterial hypoxemia (partial pressure of arterial oxygen \[PaO2...
Detailed Description
This is an interventional study evaluating the beneficial impact of verticalization of patients with ARDS on pathophysiological parameters. This therapeutic study aims to test patient's position usin...
Eligibility Criteria
Inclusion
- Patient with moderate or severe Acute Respiratory Distress Syndrome (ARDS) (PaO2/FiO2 \< 200 mmHg), at their early phase (\< 12h), under invasive mechanical ventilation with controlled ventilation (intubation or tracheotomy).
- Patient equipped with an arterial catheter.
- Patient sedated (BIS between 30 and 50) and, if necessary, under neuromuscular blocking agent (TOF \< 2/4 at the orbicular) to avoid inspiratory effort.
- Patient hemodynamically optimized following the Swan-Ganz catheter data.
Exclusion
- Refusal to participate in the proposed study.
- Unavailability of the bed dedicated to verticalization (Total Lift Bed™, VitalGo Systems Inc., Arjo AB)
- Obesity with BMI ≥ 35 kg.m-2
- Significant hemodynamic instability defined as an increase of more than 20% in catecholamine doses in the last hour, despite optimization of blood volume, for a target mean blood pressure between 65 and 75 mmHg.
- Contraindication to the insertion of a nasogastric tube
- Contraindication to the use of the chest electrical impedance tomography
- Contraindication to the insertion of a Swan-Ganz catheter
- Contraindication to the application of compression stockings
- Patient under guardianship
- Pregnancy
Key Trial Info
Start Date :
March 30 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 14 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04371016
Start Date
March 30 2020
End Date
January 14 2021
Last Update
August 25 2021
Active Locations (1)
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1
CHU
Clermont-Ferrand, France, 63000