Status:
WITHDRAWN
Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers
Lead Sponsor:
St. Joseph's Healthcare Hamilton
Conditions:
Corona Virus Infection
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The objectives of PROVIDE are to: 1. Determine if prophylactic once weekly hydroxychloroquine reduces the incidence of conversion from SARS-2-CoVnasopharyngeal swab negative to positive 2. To determi...
Eligibility Criteria
Inclusion
- 18 years of age or older to participate.
- Healthcare workers with primary practice in intensive care unit, general internal medicine,
- COVID-19 testing centres, emergency rooms, and nursing homes.
- COVID\_19 symptom free at the time of randomization and have a negative diagnostic swab.
Exclusion
- Known COVID-19 positivity defined as: a laboratory confirmed case as defined by the local public health institutes
- Suspected COVID-19 positivity defined as possessing symptoms consistent with COVID-19 infections such as: headache, fever, nausea, vomiting, diarrhea, dyspnea, dry cough
- Healthcare workers with pre-existing retinopathy or serious visual problems
- Healthcare workers with known malignancies receiving active chemotherapy or immune modifying medications
- Healthcare workers with known autoimmune disorders
- Healthcare workers with known QT prolongation
- History of ventricular arrhythmias
- Participants at risk of malignant arrythmias ○ At risk defined as: A sudden loss of consciousness with injury; anyone in their immediate family, under the age of 45year, with sudden cardiac death; anyone family history of long QT syndrome
- Known sensitivity/allergy to hydroxychloroquine
- Healthcare workers that are currently pregnant
- Healthcare workers that are already taking chloroquine or hydroxychloroquine
- Healthcare workers on colchicine or any other anti-viral medication
- Healthcare workers taking a medication that may interact with hydroxychloroquine (see table below
- Inability to take oral medications
- Inability to provide written consent
- Known G6PD deficiency
Key Trial Info
Start Date :
May 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 30 2020
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04371523
Start Date
May 1 2020
End Date
August 30 2020
Last Update
September 27 2021
Active Locations (1)
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1
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada, L8N 4A6