Status:
UNKNOWN
Effect of Antiinflammatory Treatment Versus Hand Training on Neuropsychiatric Comorbidity in RA-patients
Lead Sponsor:
Vastra Gotaland Region
Conditions:
Rheumatoid Arthritis
Pain
Eligibility:
All Genders
45-75 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate how RA affect the brain structures in RA-patients and if anti-inflammatory treatment that target TNF-α or JAK OR physical training of hands has positive imp...
Detailed Description
Based on the information gained in previous studies the investigators want to examine if; A. anti-inflammatory treatment that target TNF-α or JAK signalling or B. physical training of hands has a p...
Eligibility Criteria
Inclusion
- confirmed RA diagnosis, in the early stage of the disease (1-3 years after the diagnosis, n=20); in the established stage of the disease (5-8 years after the diagnosis, n=30) and in the late stage of the disease (\>12 years after the diagnosis, n=30)
Exclusion
- any conditions precluding MRI imaging; e.g claustrophobia; pacemaker etc, medical history of ischemic stroke or cerebral hemorrhage; medical history of neurological disease; inability to read and communicate in Swedish, hence being able to give informed consent and fill out study questionnaires
Key Trial Info
Start Date :
October 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
212 Patients enrolled
Trial Details
Trial ID
NCT04378621
Start Date
October 1 2020
End Date
September 1 2025
Last Update
May 4 2022
Active Locations (1)
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1
Clinical Rheumatology Research Center (CRRC), Department of Rheumatology, Sahlgrenska University Hospital
Gothenburg, Sweden