Status:
UNKNOWN
Comprehensive Molecular Diagnosis and Management of Hospital- and Ventilator-associated Pneumonia in Norway
Lead Sponsor:
Vestre Viken Hospital Trust
Collaborating Sponsors:
Haukeland University Hospital
University of Bergen
Conditions:
Pneumonia, Ventilator-Associated
Hospital-acquired Pneumonia
Eligibility:
All Genders
18+ years
Brief Summary
HVAPNOR consists of Three work packages: 1. Prospective observational study of Hospital (HAP) - and ventilator-Associated pneumonia (VAP) at 5 hospitals in Norway. Establish optimized routines for mi...
Detailed Description
Lower respiratory tract infections include hospital-acquired pneumonia (HAP) and ventilator- associated pneumonia (VAP) with a very high mortality in critically ill patients. Diagnosis is difficult wi...
Eligibility Criteria
Inclusion
- A case definition of NV-HAP and VAP will be applied according to the 2005 American Thoracic Society and Infectious Disease Society of America´s clinical practice guidelines (unchanged in the 2016 revision).
- Inclusion criteria:
- Age ≥18 years
- Meets case definition criteria (patient admitted to hospital or endotracheal intubation ≥ 48 hours, a new lung infiltrate + ≥2 of the following: temperature \>38˚C, leukocytes \<3.5 or \>11.0, purulent secretions)
- Eligible for lower airways sampling
- Written informed consent
- Exclusion criteria:
- Pulmonary embolism, segmental or larger
- Refractory septic shock (meeting the Sepsis-3 definition of septic shock, and requiring vasopressors ≥ 0.5 mcg/kg/min noradrenaline or equivalent dose of other vasopressor(s)
- Glasgow Coma Scale score 3
- Patients not eligible for lower airways sampling
- Palliative situation with life expectancy \< 1 week
Exclusion
Key Trial Info
Start Date :
June 15 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
550 Patients enrolled
Trial Details
Trial ID
NCT04381247
Start Date
June 15 2021
End Date
December 1 2024
Last Update
December 6 2021
Active Locations (1)
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1
Vestre Viken Health Trust
Drammen, Akershus, Norway, 3004