Status:
ACTIVE_NOT_RECRUITING
Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?
Lead Sponsor:
ART Fertility Clinics LLC
Conditions:
Infertility
IVF
Eligibility:
FEMALE
18-40 years
Brief Summary
A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention. To date, applications in orthopedics, wo...
Detailed Description
POI is a loss of normal function before age 40, leading to infertility and hypergonadotropic hypoestrogenism. Currently, no optimal regimen exists to ameliorate ovarian function. The options to concei...
Eligibility Criteria
Inclusion
- Signed and dated informed consent
- Women 40 years of age and younger with documented primary ovarian insufficiency (12).
- Normal Karyotype
- BMI \</= 35 kg/m2
- Oligo/amenorrhea for at least 4 months
- FSH \> 25 IU/mL
- AMH \</= 0,1 ng/ml
- No evidence of follicles \> 4mm
- Must have two ovaries of approximately equal volume.
- Willingness to undergo further fertility treatment, including IVF if there is evidence of response
- A transvaginal scan including Doppler for arteria ovarica will be performed previously to the surgical procedure.
Exclusion
- Premature ovarian failure due to a genetic origin, such as Turner's Syndrome or chromosomal abnormality.
- Oncological diseases (specially, skeletal system and blood).
- Autoimmune diseases, for example, lupus erythematosus, etc.
- Previous treatments including radiotherapy or chemotherapy.
- Other conditions not suitable for surgical procedures and/or anesthesia.
- Anticoagulant or antiaggregant treatment.
- Acute and chronic infectious diseases.
- Active substance abuse or dependence.
- Major Mental health disorder.
Key Trial Info
Start Date :
April 25 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT04381299
Start Date
April 25 2021
End Date
December 31 2025
Last Update
February 19 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
ART Fertility Clinics LLC
Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates, 60202