Status:
COMPLETED
Evaluation of Saliva IL-6 Levels and Periodontitis
Lead Sponsor:
University of Messina
Conditions:
Periodontal Diseases
Eligibility:
All Genders
35-65 years
Brief Summary
The aim of this study was to analyze the association between salivary IL-6 levels in patients with periodontitis. Furthermore, the objective was to determine if the periodontitis influenced salivary I...
Detailed Description
Forty-nine patients with periodontitis and 47 healthy subjects (HS) were enrolled in the present study. Enrolled patients were examined and characterized for clinical and blood samples analysis, and s...
Eligibility Criteria
Inclusion
- Presence of at least 16 teeth
- CP with a minimum of 40% of sites with a clinical attachment level (CAL)
- ≥2mm and probing depth (PD) ≥4mm;
- Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
- Presence of ≥40% sites with bleeding on probing (BOP)
Exclusion
- Intake of contraceptives
- Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- Status of pregnancy or lactation
- Previous history of excessive drinking
- Allergy to local anaesthetic
- Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
Key Trial Info
Start Date :
November 8 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 25 2019
Estimated Enrollment :
287 Patients enrolled
Trial Details
Trial ID
NCT04382105
Start Date
November 8 2015
End Date
September 25 2019
Last Update
November 24 2020
Active Locations (1)
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1
University of Messina
Messina, Italy, 98100