Status:
COMPLETED
Bowel Colonization With Multi-drug Resistant Bacterial Species in Hospitalized Patients With acute-on Chronic Liver Failure (ACLF), and Its Relationship With Extra-intestinal Infectious Events and Short-term Outcomes.
Lead Sponsor:
Institute of Liver and Biliary Sciences, India
Conditions:
Acute-On-Chronic Liver Failure
Eligibility:
All Genders
18-60 years
Brief Summary
Bowel colonization with anti-microbial resistant bacteria increases the risk of clinical infections. Infections caused by anti-microbial resistant bacteria have been associated with increased mortalit...
Eligibility Criteria
Inclusion
- \- Patients with Acute on Chronic Liver Failure admitted to the ward/High Dependency Unit/Intensive Care Unit.
Exclusion
- Patients on immunosuppressant medications or on daily steroids (excluding inhaled steroids) or \>2 weeks.
- Patients with additional primary or acquired immunosuppressive states like hypogammaglobinemia, post-splenectomy, human immunodeficiency virus (HIV) infection etc.
- Neutropenia defined as absolute neutrophil count or total white blood cell count (WBC) \<500/mm3
- Patients with extra-hepatic malignancy or on cytotoxic chemotherapy.
- Patients with ileus, bowel hypomotility, severe constipation requiring laxatives/purgatives or enemas to evacuate.
- Patients with fresh or altered blood in stools.
- Patients with anatomical predisposition to infection/ bacterial seeing like prosthesis or foreign body. Patients with exfoliative skin conditions, significant mucosal ulcerations, or skin ulcers. Patients who have received \> 2 weeks of antibiotics before current admission.
- Pregnant patients.
Key Trial Info
Start Date :
June 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2021
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04383106
Start Date
June 1 2020
End Date
December 31 2021
Last Update
March 5 2024
Active Locations (1)
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1
Institute of Liver and Biliary Sciences
New Delhi, National Capital Territory of Delhi, India, 110070