Status:
COMPLETED
Probiotic Lozenges for Treatment of Recurrent Aphthous Stomatitis
Lead Sponsor:
Reham Lotfy Aggour
Conditions:
Oral Ulcer
Eligibility:
All Genders
3-45 years
Phase:
NA
Brief Summary
The application of host-modulating bacteria for therapeutic purposes is one of the strongest emerging fields. Probiotics are live microorganisms, which, when administered in an adequate amount, confer...
Detailed Description
The study aimed to explore the effectiveness of probiotics in the treatment of minor recurrent aphthous stomatitis (RAS). We performed a randomized, controlled clinical study. Sixty adult (group A) an...
Eligibility Criteria
Inclusion
- Males and females aged 18-45 years old, 2. Patients presenting with RAS with the following characteristics: a. Minor aphthous ulcers less than 48 hours' duration prior to enrolment, b. Size no greater than 10 mm in diameter, c. A history that ulcers normally more than 5 days to resolve without treatment. The inclusion criteria for group B is the same except age, children with RAS aged between 3 and 12 years were recruited for the study.
Exclusion
- A known history of hypersensitivities, immunologic or systemic diseases, pregnancy, smoking,
- treatment with systemic steroid or other immunomodulatory agents within 1 month before the study
- use of nonsteroidal anti-inflammatory drugs or oral antihistamines within 1 month prior to the study
- treatment of the ulcer with any preparation or medication within 72 hours prior to the study
- treatment with systemic antibiotics within 2 weeks prior to the study and a history of adverse reactions to lactose or fermented milk products.
- Children with a positive family history of RAS were excluded.
Key Trial Info
Start Date :
December 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 21 2019
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04383236
Start Date
December 1 2016
End Date
April 21 2019
Last Update
May 12 2020
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