Status:
UNKNOWN
Curosurf® in Adult Acute Respiratory Distress Syndrome Due to COVID-19
Lead Sponsor:
Dr Christophe LENCLUD
Conditions:
COVID-19
ARDS, Human
Eligibility:
All Genders
18-100 years
Phase:
PHASE2
Brief Summary
Surfactant replacement therapy (SRT) improves oxygenation and survival in NRDS and some infant ARDS. SRT was tried in adult ARDS with conflicting results. Research by Filoche and Grotberg helped to un...
Eligibility Criteria
Inclusion
- At least 18 years
- Intensive care unit admission.
- Intubation and mechanical ventilation since less than 72h.
- Positive end-expiratory pressure ≥ 5 cmH2O.
- Acute respiratory distress syndrome following Berlin definition.
- COVID-19
- PaO2/FiO2 ratio \< 150 mmHg during at least 3 hours despite PEP trial.
- Compliance of the respiratory system \< 50 mL/cmH2O
Exclusion
- Contraindication to prone position.
- Pregnancy.
- Weight \< 40 kg
- height \< 140 cm or height \> 190 cm.
- Profuse bronchorrhea (at least 1 succion per hour during 3 hours).
- Other significant cause than ARDS to the respiratory failure.
- Decision to limit active therapies.
- No arterial line in place.
- Obesity with weight / height ratio \> 1 kg / cm.
- Impossible to give neuromuscular blockers (e.g. drug unavailable owing to global pandemia).
- Severe chronic respiratory failure with oxygen at home.
- Other severe acute or chronic organ faillure (eg severe liver cirrhosis, severe chronic cardiac failure).
- History of pneumonectomy or pulmonary lobectomy.
- Patient scheduled for extracorporeal membrane oxygenation.
- Known hypersensibility to Curosurf.
- Contraindication to bronchial fibroscopy.
- Person under legal protection.
Key Trial Info
Start Date :
May 29 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04384731
Start Date
May 29 2020
End Date
July 31 2021
Last Update
February 3 2021
Active Locations (1)
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1
CH Francois Quesnay
Mantes-la-Jolie, France