Status:
COMPLETED
The Ability of Pecan Consumption to Improve Vascular Function and Reduce Chronic Disease Risk in Aging Adults
Lead Sponsor:
University of Georgia
Collaborating Sponsors:
American Pecan Council
Conditions:
Aging
Eligibility:
All Genders
50-75 years
Phase:
NA
Brief Summary
Background: To date, there are no published studies on the effects of pecans on vascular function following a high-fat meal. Purpose: To examine the impact of daily pecan consumption for a 4-week per...
Detailed Description
This will be a randomized, controlled trial in men and postmenopausal women (50-75y). Subjects will be randomized into one of the two study groups: a control group (CON) following their usual diet, or...
Eligibility Criteria
Inclusion
- Men and postmenopausal women (without menses for 1 yr and follicle stimulating hormone \> 30 IU/mL) between the ages of 50-75y
- Body mass indexes (BMI) between 18-34.9kg/m2
Exclusion
- Nut consumption \>2 servings/week or tree nut butter consumption \>3 servings/week
- Pre-menopausal and menopausal women, hormone replacement therapy if less than 2 years
- Regularly exercise more than 3 h/week
- Weight gain or loss more than 5% of their body weight in the past 3 months
- Plans to begin a weight loss/exercise regimen during the trial
- Gastrointestinal surgeries, conditions or disorders
- History of medical or surgical events that could affect swallowing
- Chronic or metabolic diseases
- Previous MI, stroke, or cancer
- Fasting blood glucose levels greater than 126 mg/dL
- Blood pressure greater than 180/120 mmHg
- Medication use affecting digestion and absorption, metabolism
- Lipid-lowering medications
- Medications for diabetes, depression, or ADD/ADHD
- Regular use of medications known to affect endothelial function or blood vessel tone
- Blood pressure medication and steroid/hormone therapies
- Individuals on a medically prescribed or special diet
- Individuals with food allergies to foods specifically in the study
- Excessively use alcohol (greater than 3 drinks/d for men; greater than 2 drinks/d for women)
- Tobacco or nicotine use
- Individuals taking fish oil and omega-3 fatty acid supplements
- Significant head trauma or brain surgery
- A score \>26 on the Beck's Depression Inventory II (BDI-II)
- A score \<24 on the Mini-Mental State Examination (MMSE) will be excluded.
Key Trial Info
Start Date :
September 17 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 16 2022
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04385537
Start Date
September 17 2020
End Date
April 16 2022
Last Update
May 24 2022
Active Locations (1)
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1
University of Georgia- Department of Foods and Nutrition
Athens, Georgia, United States, 30605