Status:
UNKNOWN
Maneuver for Evaluating the Potential Recruitability of the Pulmonary Parenchyme in Patients With ARDS
Lead Sponsor:
University Hospital, Caen
Conditions:
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
This study will try to define the threshold of the recruitable volume (Vrec), obtained by a derecruitment maneuver, that permit to identify patients responder or not to alveolar recruitment maneuvers.
Detailed Description
Background: Acute respiratory distress syndrome (ARDS) is characterized by a major loss of lung volume due to alveolar flooding, atelectasis and consolidation. Alveolar recruitment maneuvers (ARM) pe...
Eligibility Criteria
Inclusion
- Moderate to severe ARDS as per the Berlin definition (Partial pressure of oxygen (PaO2)/Fraction of inspired oxygen (FiO2) \< 200 mmHg) and within 72h of onset, with a FiO2 \> 60%
- Receiving assist/control mechanical ventilation with continuous sedation and neuromuscular blocker
- In supine position during the procedures and measurements
- Patients \> 18 years of age
Exclusion
- Patients \< 18 years of age
- Pregnant woman
- Patient deprived of freedom or under a legal protective measure
- Hemodynamic instability defined as a mean arterial pressure \< 65 mmHg or increasing doses of vasopressor drugs
- Pneumothorax, pneumomediastinum, pleural fistula, sub-cutaneous emphysema
- Chronic or recent severe cardiac dysfunction
- Patient with a PEEP \> 15 cmH20 before inclusion
- Patient with no therapeutic perspective; candidate for palliative care exclusively or with end of life decision before inclusion
Key Trial Info
Start Date :
April 12 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT04387669
Start Date
April 12 2020
End Date
December 31 2021
Last Update
May 14 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Centre Hospitalier Universitaire - CHU Caen
Caen, France, 14000