Status:
COMPLETED
Intraosseous Morphine in Primary TKA
Lead Sponsor:
The Methodist Hospital Research Institute
Conditions:
Knee Disease
Arthritis Knee
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The research team wants to investigate if an intraosseous injection (directly into the bone marrow) of morphine during primary total knee replacement helps with post-operative pain following primary t...
Eligibility Criteria
Inclusion
- Patient gives informed consent to participate in the study
- Patient is undergoing a primary total knee arthroplasty.
- Age \> 18 and \<80 years old.
Exclusion
- Patient lacks the capacity to consent to the research project (study will not utilize LAR signatures during the informed consent process)
- Weigh \< 100 pounds
- BMI \> 35
- Pregnancy or suspected pregnancy
- Past medical history of opioid addiction.
- Established hypersensitivity (ie allergy) to morphine.
- Acute or chronic liver disease for example cirrhosis.
- Use of any narcotics 5 days before surgery (opioids, hydrocodone, morphine, hydromorphone, fentanyl, etc).
- Undergoing bilateral total knee replacement, revision total knee arthroplasty, or any additional procedure outside of a primary total knee arthroplasty.
- Unable to get general and spinal anesthesia.
Key Trial Info
Start Date :
May 5 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2021
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT04388111
Start Date
May 5 2020
End Date
May 31 2021
Last Update
September 19 2024
Active Locations (1)
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1
Houston Methodist Hospital
Houston, Texas, United States, 77030