Status:
WITHDRAWN
OVSTAR TIL Trial (OVarian Cancer Co-STimulatory Antigen Receptor TIL Trial)
Lead Sponsor:
Immetacyte Ltd
Conditions:
Ovarian Cancer Metastatic
Eligibility:
FEMALE
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
An open label, multi-centre Phase 1/2a study of modified and unmodified autologous Tumour Infiltrating Lymphocytes (TIL) in patients with platinum-resistant ovarian cancer. The purpose of this phase I...
Detailed Description
This is a single-arm Phase 1/2a study of unmodified (UTIL-01) and gene modified (CoTIL-01) adoptive TIL therapy which will enrol sequentially. A total of 8 patients will be recruited to the UTIL-01 co...
Eligibility Criteria
Inclusion
- Criteria for Pre-Screening Phase
- Patients are eligible to be included in the pre-screening phase of the study only if all of the following criteria apply:
- Women with histologically confirmed recurrent metastatic platinum-resistant high-grade serous ovarian cancer (HGSOC) (platinum resistant defined as progressing within 6 months of last platinum-containing combination chemotherapy. Patients must have received at least 1 line of prior platinum-containing combination chemotherapy and have completed at least 4 cycles of this treatment).
- Expected to fulfil all entry criteria for OVSTAR Main Study
- Written informed consent to Pre-Screening
- Measurable disease by Response Evaluation Criteria in Solid Tumours 1.1
- Have disease suitable for fresh TIL harvesting from tumour biopsies (only applicable to patients who are not participants of Sponsor's Tumour Collection Programme, PRIME)
- Medically suitable for a general anaesthetic and surgical biopsy (only applicable to patients who are not participants of Sponsor's Tumour Collection Programme, PRIME)
- Women of child bearing potential must be willing to practise a highly effective method of birth control once consented to pre-screening
- World Health Organisation (WHO) Performance Status of 0 or 1 (Appendix 3)
- Age equal to or greater than 18 years
- Life expectancy \> 6 months
- Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the Pre-Screening or Main Study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial
- Seronegative for HIV antibody, Hep B antigen, Hep C antibody and syphilis
- Haematological and biochemical indices
Exclusion
- Exclusion for Pre-Screening Phase
- Patients will not be invited to participate in Pre-Screening if any of the following criteria apply:
- History of a previous malignancy at another site, unless followed for \>2 years with no sign of recurrent disease (local completely excised cutaneous basal cell, squamous cell carcinoma or in situ carcinoma will be allowed).
- Patients receiving chemotherapy, targeted therapy, immunotherapy or systemic steroids including steroid doses \>10mg/day of prednisolone (or equivalent) during the previous four weeks prior to TIL harvesting. Patients who require such therapies intermittently due to pre-existing disorders are also excluded.
- Evidence of any active significant infection.
- Patients who have any malignant or likely malignant Central Nervous System (CNS) lesion visible on CT.
- Evidence of clinically significant immunosuppression such as primary immunodeficiency (e.g. severe combined immunodeficiency disease).
- Clinically significant cardiac disease. Examples would include unstable coronary artery disease, myocardial infarction within 6 months or class III or IV American Heart Association criteria for heart disease.
- Patients who are at high medical risk because of non-malignant systemic disease including those with uncontrolled cardiac or respiratory disease, or other serious medical or psychiatric disorders which, in the lead clinician's opinion, would not make the patient a good candidate for adoptive TIL therapy.
- Severe and active autoimmune disease.
- On concomitant treatment with other experimental drugs within 4 weeks of TIL harvesting.
- Patients not considered likely to comply with required follow up.
- Patients with severe allergies, history of anaphylaxis or known allergies to the administered drugs.
- Patients who have received any prior adoptive cell therapy or organ transplant (including stem cells).
- Patients who are pregnant or breast feeding should be excluded from pre-screening
- Patients with any contraindications to any of the components of the study Non Investigational Medicinal Products (cyclophosphamide, fludarabine, Interleukin-2) will be excluded
- Patents who have received live vaccines within 4 weeks prior to TIL therapy will be excluded
- Inclusion for Main Study
- Patients are eligible to be included in the Main Study only if all of the following criteria, and the inclusion criteria listed in Section 1.3.1, apply:
- Women with metastatic platinum resistant high-grade serous ovarian cancer (HGSOC) who have recurrent disease (platinum resistant defined as progressing within 6 months of last platinum-containing combination chemotherapy. patients must have received at least 1 line of prior platinum-containing combination chemotherapy and have completed at least 4 cycles of this treatment).
- Informed consent to Main Study
- Confirmation from Sponsor of successful TIL growth
- Measurable disease (by Response Evaluation Criteria in Solid Tumors 1.1) on CT within 4 weeks of main study entry
- Left ventricular ejection fraction \>50% on Echocardiogram scan
- Patients must be willing to practice a highly effective method of birth control during treatment and for four months after receiving the preparative regime if appropriate.
- World Health Organisation (WHO) Performance Status of 0 or 1 (Appendix 3)
- Age equal to or greater than 18 years
- Life expectancy \> 6 months
- Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the Pre-Screening or Main Study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial
- Seronegative for HIV antibody, Hep B antigen, Hep C antibody and syphilis
- Haematological and biochemical indices
- Exclusion for Main Study
- Patients receiving day 1 of their last cycle of chemotherapy or targeted therapy less than four weeks prior to pre-conditioning chemotherapy.
- Patients receiving systemic immunosuppressive therapy including steroids at doses higher than 10mg/day of prednisolone (or equivalent) within four weeks of commencing pre-conditioning chemotherapy (unless this is required briefly as anti-emetic prophylaxis for the treatments detailed in above point 1). Patients who require such therapies intermittently due to pre-existing disorders are also excluded.
- Patients who have any malignant or likely malignant Central Nervous System (CNS) lesion visible on CT.
- Evidence of any active significant infection.
- Evidence of clinically significant immunosuppression such as primary immunodeficiency (e.g. severe combined immunodeficiency disease).
- Clinically significant cardiac disease. Examples would include unstable coronary artery disease, myocardial infarction within 6 months or class III or IV American Heart Association criteria for heart disease.
- Patients who are at high medical risk because of non-malignant systemic disease including those with uncontrolled cardiac or respiratory disease, or other serious medical or psychiatric disorders which, in the lead clinician's opinion, would not make the patient a good candidate for adoptive TIL therapy.
- Severe and active autoimmune disease.
- Receiving concomitant treatment with any other experimental drugs within 4 weeks of pre-conditioning chemotherapy. Patients receiving experimental immunotherapies will be discussed with the sponsor.
- Patients not considered likely to comply with required follow up.
- Patients with severe allergies, history of anaphylaxis or known allergies to the administered drugs.
- Patients who are pregnant or breast feeding should be excluded from entering the study
- Patients who have received any prior adoptive cell therapy or organ transplant (including stem cells).
- Caution should be exercised for patients requiring regular drainage of ascites or pleural effusions. When there is sufficient fluid to be safely drained, drainage must be performed prior to trial enrolment and pre-conditioning chemotherapy in those patients.
- Patients with any contraindications to any of the components of the study Non Investigational Medicinal Products (cyclophosphamide, fludarabine, Interleukin-2) will be excluded
- Patents who have received live vaccines within 4 weeks prior to TIL therapy will be excluded.
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2025
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04389229
Start Date
July 1 2020
End Date
July 31 2025
Last Update
December 16 2020
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Queens Elizabeth Hospital
Birmingham, United Kingdom
2
The Christies Hospital
Manchester, United Kingdom