Status:
UNKNOWN
Prone Positioning and High-flow Nasal Cannula in COVID-19 Induced ARDS
Lead Sponsor:
Hospital Universitari Vall d'Hebron Research Institute
Conditions:
COVID
ARDS
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Prone position (PP) has been proved to be effective in severe ARDS patients. On the other hand, High flow nasal cannula (HFNC) may prevent intubation in hypoxemic Acute respiratory failure (ARF) patie...
Eligibility Criteria
Inclusion
- COVID-19 pneumonia according to the diagnostic criteria in effect at the time of inclusion or very strongly suspected.
- Patient treated by nasal high flow.
- Moderate or severe ARDS: bilateral radiological opacities not explained entirely by effusions, atelectasis or nodules; acute hypoxemia with worsening within the 7 previous days, not entirely explained by left ventricular failure; PaO2 / FiO2 ratio \<300 mmHg (or SpO2 / FiO2 equivalent).
- Informed consent.
- Beneficiary or affiliated to a social security scheme.
Exclusion
- Indication of immediate tracheal intubation
- Significant acute progressive circulatory insufficiency
- Impaired alertness, confusion, restlessness
- Body mass index\> 40 kg / m2
- Chest trauma or other contraindication to prone position
- Pneumothorax
- Vulnerable person: safeguard of justice
- Pregnant or lactating woman
Key Trial Info
Start Date :
May 13 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
248 Patients enrolled
Trial Details
Trial ID
NCT04391140
Start Date
May 13 2020
End Date
June 1 2021
Last Update
August 18 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital Universitari Vall d'Hebron
Barcelona, Spain, 08035