Status:
COMPLETED
Heart Rhythm After Intravenous Methylprednisolone Administration
Lead Sponsor:
Medical University of Warsaw
Conditions:
Graves Disease
Graves Ophthalmopathy
Eligibility:
All Genders
18+ years
Brief Summary
High doses of intravenous (iv.) glucocorticoids (GCs) are commonly used as a treatment for many autoimmune and inflammatory disorders. According to the European Group on Graves' Orbitopathy (EUGOGO) g...
Detailed Description
The clinical status of patients was evaluated before each pulse, including blood pressure monitoring, glucose level monitoring and symptoms of infection. HR and BP was measured continuously for 3 cons...
Eligibility Criteria
Inclusion
- active, moderate-to-severe GO according to EUGOGO classification
- euthyroidism
- completion of 12 IVMP pulses.
Exclusion
- cardiovascular morbidity (such as chronic heart failure and/or coronary heart disease)
- uncontrolled hypertension (defined as systolic blood pressure (SBP) more than 140 mmHg and/or diastolic blood pressure (DBP) more than 90 mmHg)
- contraindications to IVMP therapy
- previous GCs treatment in the last 6 months.
Key Trial Info
Start Date :
January 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 20 2020
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04391439
Start Date
January 1 2011
End Date
February 20 2020
Last Update
May 18 2020
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