Status:
UNKNOWN
Effects of Cardiovascular and Pulmonary Optimization on Cerebral Oxygenation in COVID-19 Patients With Severe ARDS
Lead Sponsor:
Hvidovre University Hospital
Conditions:
COVID-19
Respiratory Failure
Eligibility:
All Genders
18+ years
Brief Summary
The aim of the present study is to examine whether cerebral oxygenation could be a more useful parameter than peripheral oxygen saturation to guide clinical titration of permissive hypoxemia in COVID-...
Detailed Description
Mechanical ventilation is the cornerstone of supportive management for most ARDS patients to prevent life-threatening hypoxemia. Arterial oxygenation can be improved via ventilator by increasing fract...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Verified COVID-19 infection (throat swab or tracheal aspirate positive for SARS-CoV-2)
- Severe ARDS according to Berlin definition
- Ventilator settings: Controlled IPPV, FiO2 \> 0.70, PEEP \> 10
- Norepinephrine infusion
- SVV \< 10% measured by LiDCO
- RASS - 5
Exclusion
- Any of the following contraindications to lung recruitment: pneumothorax, patients on ventilator \> 1 week
- Patients with dark pigmented skin
Key Trial Info
Start Date :
May 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04392089
Start Date
May 1 2020
End Date
May 1 2021
Last Update
May 18 2020
Active Locations (1)
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1
Hvidovre Hospital
Copenhagen, Denmark