Status:
UNKNOWN
Spasticity After Spinal Cord Injury
Lead Sponsor:
Shirley Ryan AbilityLab
Conditions:
Spinal Cord Injuries
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Very often, people who have a SCI have difficulty doing things with their arms or hands as a result of muscle stiffness , or spasticity. Spastacity can cause problems performing even the simplest of e...
Detailed Description
After spinal cord injury (SCI), damage to descending motor pathways has been associated with the development of spasticity (Frigon and Rossignol, 2006; Trompetto et al., 2014). Self-reported questionn...
Eligibility Criteria
Inclusion
- Inclusion criteria for individuals with SCI
- Chronic SCI (≥1 year of injury)
- Incomplete spinal cord injury at T12 or above
- Males and Females
- Ages 18-75 years
- Inclusion criteria for non-spastic individuals with SCI
- MAS scores of 0 and 1
- Inclusion criteria for spastic individuals with SCI
- MAS scores of 2, 3 and 4
- The ability to perform a voluntary flexion and extension of the elbow and/or knee or ankle
- The ability to reach and grasp an object
- Inclusion criteria for health controls
- Males and females
- Ages 18-75 years
- Right-handed
- Able to perform elbow and/or knee or ankle flexion and extension
- Exclusion Criteria for individuals with SCI and healthy controls:
- Uncontrolled medical problems including pulmonary, cardiovascular, or orthopedic disease
- Any debilitating disease prior to the SCI that caused exercise intolerance
- Premorbid, ongoing major depression or psychosis, altered cognitive status
- History of head injury or stroke
- Pacemaker
- Metal plate in skull
- History of seizures
- Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants
- Pregnant females
- Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida, or herniated cervical disk
Exclusion
Key Trial Info
Start Date :
May 13 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 18 2024
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04393922
Start Date
May 13 2020
End Date
May 18 2024
Last Update
June 22 2022
Active Locations (1)
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1
Shirley Ryan AbilityLab
Chicago, Illinois, United States, 60611