Status:
UNKNOWN
A Study of AB-106 in Subjects With Advanced NSCLC Harboring ROS1 Fusion Gene
Lead Sponsor:
AnHeart Therapeutics Inc.
Conditions:
Non Small Cell Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of the study is to evaluate safety, pharmacokinetics and efficacy of AB-106 monotherapy in the treatment of advanced NSCLC.
Detailed Description
This is a Phase II, multicenter, single-arm, open label study of AB-106 in the Chinese patients with advanced NSCLC harboring ROS1 fusion gene.The study will be divided into two stages. First stage (S...
Eligibility Criteria
Inclusion
- Patients must meet all of the following criteria to be eligible for enrollment into the study:
- ≥ 18 years of age
- Histologically or cytologically confirmed locally advanced or metastatic NSCLC
- Positivity of ROS1 fusion is determined by the local qualified laboratories by using the FISH, RT-PCR or NGS assay, and the subject must provide archival tumor tissue sample for the confirmation by a sponsor-designated central laboratory
- The subject is either TKI treatment naïve(Cohort A)， or has disease progression following the treatment of crizotinib （Cohort B）
- The patient with brain metastases is either asymptomatic, or neurologically stable for at least 2 weeks prior to study entry
- Prior therapies (including chemotherapies \[less than 3 lines of regimen\], radiotherapy \[except for palliative\], or surgery) should be completed at least 2 weeks prior to study entry. The palliative radiotherapy (≤10 times) should be completed within 48 hours prior to study entry. Any acute toxic effect must be resolved to CTCAE Grade ≤1 except for alopecia
- At least one measurable target tumor lesion (as accessed by RECIST v1.1) that has not been irradiated
- ECOG Performance Status: 0 or 1
- Patient with a life expectancy ≥ 3 months based on the judgement of investigators
- Adequate organ functions defined by the following criteria：
- Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) ≤2.5 x ULN; or ≤5 x ULN， if there is liver metastases involvement；
- Total serum bilirubin ≤1.5 x ULN；
- Absolute neutrophil count（ANC） ≥1500/µL；
- Platelet count≥100,000/µL；
- Hemoglobin≥8.0 g/dL；
- Serum creatinine ≤2 x ULN. 11. Evidence of a personally signed and dated informed consent document indicating that the patient has been informed of the pertinent aspect of the study 12. Willingness and ability to comply with the study scheduled visits, treatment plans, laboratory tests and other procedures 13. Male and female patients of childbearing potential must agree to sue effective methods of contraception throughout the study and for 90 days after the last dose of study medication.
Exclusion
- Patient presenting with any of the following criteria will not be included in the study：
- Current participation in other therapeutic investigational studies
- Previous participation in the treatment or clinical trials of other ROS1-TKIs (except for crizotinib)
- Previous participation in the treatment and clinical trials of ALK or NTRK fusion gene targeted therapies.
- Spinal cord compression unless the patient demonstrates good pain control and stabilization or recovery of neurological function, carcinomatous meningitis or leptomeningeal disease
- Patients with interstitial fibrosis or interstitial lung disease
- Any one of the following currently or in the previous 3 months: myocardial infarction, severe/unstable angina, coronary/ peripheral artery bypass graft, congestive heart failure or cerebrovascular accident including transient ischemic attack
- Ongoing cardiac dysrhythmias of NCI CTCAE (v5.0) Grade≥2, uncontrolled atrial fibrillation of any grade, or QTc interval\>470 microsec
- Pregnancy or breastfeeding
- Current use of food or drugs that are known strong CYP3A inhibitors, including (but not limited to) atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin, voriconazole, grapefruit or grapefruit juice.
- Current use of drugs that are known strong CYP3A4 inducers, including (but not limited to) carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, and St John's Wort
- Current use of drugs that are known CYP3A4 substrates with narrow therapeutic indices, including (but not limited to) dihydroergotamine, ergotamine, pimozide, astemizole, cisapride, and terfenadine.
- Current use of drugs that are known to induce QTc prolongation
- Systematic treatment with anti-cancer therapy, including any Traditional Chinese Medicine (TCM)with anti-tumor effect indicated in the prescription information.
- Evidence of active malignancy (other than current NSCLC, non-melanoma skin cancer, in situ cervical cancer, and presumed cured prostate cancer) within the last 3 years
- Clinically active viral disease with positivity of serum HIV, HBV, HCV, RPR testing
- Difficult to swallow which may significantly impact drug absorption
- Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation in the judgement of investigator and sponsor
Key Trial Info
Start Date :
July 7 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
173 Patients enrolled
Trial Details
Trial ID
NCT04395677
Start Date
July 7 2020
End Date
December 31 2025
Last Update
October 30 2023
Active Locations (1)
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1
Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, China, 200000