Status:
COMPLETED
A Natural History of Perioperative Metabolism
Lead Sponsor:
University of Vermont Medical Center
Conditions:
Surgery
Anesthesia
Eligibility:
All Genders
18+ years
Brief Summary
The process of surgery is a controlled trauma to the body. Trauma induces changes in metabolic function that have evolved to help the body survive injury. The normal balance among use of sugar, fat, a...
Detailed Description
We will conduct a cross-sectional study in a cohort of patients undergoing spinal surgery for discectomy, laminectomy, or vertebral fixation. We will recruit a cohort of subjects in groups with metabo...
Eligibility Criteria
Inclusion
- Subjects were eligible if they were \>18 years old without acute or chronic health conditions who were undergoing multilevel lumbar fusions with an inhaled anesthetic.
Exclusion
- acute or chronic health conditions including cardiac, pulmonary, hepatic, renal, auto-immune, or hematological disease. Obese subjects with body mass index \>40kg/m2 were excluded. Subjects with Type 2 diabetes were eligible if they were well-controlled (HbA1c \<7.5%) and treated with diet and exercise, metformin, or insulin. Subjects were excluded if taking a sulfonylurea, thiazolidindiones, DPP-4 inhibitor, GLP-1 analog, weight loss medication, or other medications affecting glucose homeostasis.
Key Trial Info
Start Date :
April 14 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 31 2019
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT04396964
Start Date
April 14 2014
End Date
July 31 2019
Last Update
May 21 2020
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