Status:
UNKNOWN
Myocardial Contrast Echocardiography in Septic Patients
Lead Sponsor:
Universitair Ziekenhuis Brussel
Conditions:
Sepsis
Microcirculation
Eligibility:
All Genders
19-85 years
Phase:
NA
Brief Summary
Myocardial microcirculatory alterations may be involved in the pathogenesis of acute cardiac dysfunction or septic cardiomyopathy in septic patients. The investigators study the cardiac function (syst...
Detailed Description
Using the IE33 device (Philips Medical Systems, the Netherlands), two-dimensional and myocardial contrast echocardiography (TTE and MCE) are performed following the recommendations of the American Hea...
Eligibility Criteria
Inclusion
- Sepsis: a life-threatening organ dysfunction (defined as an acute change in total Sequential Organ Failure Assessment (SOFA) score \> 2 points consequent to infection) caused by a dysregulated host response to infection.
- Sepsis shock : a subset of sepsis with persisting hypotension requiring vasopressors to maintain the mean arterial pressure \> 65 mmHg and having a serum lactate level \> 2 mmol/L after fluid resuscitation.
Exclusion
- Non-survivors in the first 24 hours from sepsis
- Sepsis post-acute cardiac arrest
- Pregnancy
- Younger than 18 years old
- Acute Respiratory Distress Syndrome (ARDS) with the ratio of arterial oxygen partial pressure (mmHg) to fractional inspired oxygen (PaO2/ FiO2) \< 200)
- Advanced malignancy
- Untreated and unstable acute coronary syndrome
- History of myocardial infarction with severe left ventricular dysfunction. (Ejection fraction \< 20 %).
- Inoperable valvular and coronary disease
- Significant right-left cardiac shunt
- Untreated congenital heart disease
- Severe systolic pulmonary hypertension \> 80 mmHg
- Insufficient echogenicity
- Prior anaphylaxis reaction to the Sonovue microbubbles
Key Trial Info
Start Date :
January 31 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04397640
Start Date
January 31 2020
End Date
December 31 2023
Last Update
May 26 2020
Active Locations (1)
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1
Universitair Ziekenhuis Brussel
Brussels, Belgium, 1090