Status:
COMPLETED
T Cell Memory Fuels the Innate Response in Chronic CF Lung Disease
Lead Sponsor:
National Jewish Health
Collaborating Sponsors:
Cystic Fibrosis Foundation
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
18+ years
Brief Summary
This study seeks to define the role of CD4+ and CD8+ T cell memory responses in the immunologic failure of patients with cystic fibrosis (CF) to clear infections. In a normal host, the immune system c...
Eligibility Criteria
Inclusion
- Documented diagnosis of CF.
- Age 18 years old or greater.
- Hospitalization with planned IV antibiotic treatment for a pulmonary exacerbation of CF.
- Ability to perform reproducible Pulmonary Function Tests and produce sputum.
- Willingness to comply with study procedure and willingness to provide written consent.
Exclusion
- Presence of a condition or abnormality that, in the opinion of the Principal Investigator (PI), would compromise the safety of the patient or the quality of the data.
- Use of systemic steroids at the start of IV treatment for a pulmonary exacerbation
Key Trial Info
Start Date :
May 6 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2021
Estimated Enrollment :
112 Patients enrolled
Trial Details
Trial ID
NCT04397861
Start Date
May 6 2015
End Date
November 1 2021
Last Update
September 29 2022
Active Locations (1)
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1
National Jewish Health
Denver, Colorado, United States, 80206