Status:
UNKNOWN
A Randomized Clinical Trail of The Effect of Postoperative Uric Acid Control on Stone Recurrence and Renal Function in Patients With Hyperuricemia of Urolithiasis.
Lead Sponsor:
Xuhui Central Hospital, Shanghai
Conditions:
Hypouricemia, Renal
Urolithiasis
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
The purpose of this study was to explore the effects of uric acid control on stone recurrence and renal function in patients with calculi of hyperuricemia through a prospective controlled study.
Detailed Description
2020.1 -2020.12 patients with urolithiasis and hyperuricemia were enrolled in the urology department of our hospital (100 cases). The patients were informed of this study before operation and randomly...
Eligibility Criteria
Inclusion
- .Over 18 years old, under 70 years old, regardless of sex .The subjects had no mental illness or language dysfunction, could understand the situation of this study and had signed an informed consent form.
- .No clinical manifestations of urinary tract infection, urinary routine examination showed urinary tract infection, but urinary etiology test was negative (urinary routine leukocytosis), treated with broad-spectrum antibiotics for more than 3 days.
- .Clinical manifestations of urinary tract infection, urine routine examination showed urinary tract infection, and patients with positive urinary etiology were treated with sensitive antibiotics for more than 7 days.
- Serum uric acid value ≥480 µmol / L
- urinary stones
Exclusion
- Transplanted kidney
- Fever or urinary tract infection is not treated according to the inclusion criteria
- Pregnant women and female menstruation
- Unable to tolerate anesthesia or surgery due to severe systemic disease, heart disease, pulmonary insufficiency and important organ failure
- Patients with renal insufficiency Clcr \<30 mL/min
- Those who take side effects of febuxostat，Patients with side effects of febuxostat, patients with a previous history of coronary heart disease
Key Trial Info
Start Date :
April 10 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2022
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04398251
Start Date
April 10 2020
End Date
May 31 2022
Last Update
May 21 2020
Active Locations (1)
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1
Shanghai Xuhui Central Hospital
Shanghai, Shanghai Municipality, China, 200031