Status:
COMPLETED
INO-3107 With Electroporation (EP) in Participants With HPV-6- and/or HPV-11-Associated Recurrent Respiratory Papillomatosis (RRP)
Lead Sponsor:
Inovio Pharmaceuticals
Conditions:
Respiratory Papillomatosis
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
This is a Phase 1/2 open-label, multicenter trial to evaluate the safety, tolerability, immunogenicity, and efficacy of INO-3107 in subjects with HPV-6 and/or HPV-11-associated recurrent respiratory p...
Eligibility Criteria
Inclusion
- Key
- Histologically-documented HPV-6- or HPV-11-positive respiratory papilloma or documentation of low-risk positive HPV using a Sponsor approved HPV-6/11 type-specific assay
- Requirement for frequent RRP intervention to remove or resect respiratory papilloma, as defined as at least two RRP surgical (including laser) interventions in the year prior to and including Day 0
- Must be an appropriate candidate for upcoming surgical intervention as per Investigator judgment and RRP Staging Assessment score
- Adequate bone marrow, hepatic, and renal function
- Participants must meet one of the below requirements:
- Be of non-child bearing potential (≥12 months of non-therapy-induced amenorrhea, confirmed by follicle-stimulating hormone \[FSH\], if not on hormone replacement)
- Be surgically sterile (vasectomy in males or absence of ovaries and/or uterus in females)
- Agree to use one highly effective or combined contraceptive methods that result in a failure rate of \<1% per year during the treatment period and at least through week 12 after last dose
- Agree to abstinence from penile-vaginal intercourse, when this is the participant's preferred and usual lifestyle
- Key
Exclusion
- Recipient of therapy directed towards RRP disease (other than surgery or ablation) including but not limited to anti-virals (including cidofovir), radiation, chemotherapy, anti-angiogenic therapy (including bevacizumab), prophylactic HPV vaccination (including Gardasil) as therapeutic intervention, or therapy with an experimental agent within 3 months prior to Day 0
- Ongoing or recent (within 1 year) evidence of autoimmune disease that required treatment with systemic immunosuppressive treatments, with the exception of: vitiligo, childhood asthma that has resolved, type 1 diabetes, residual hypothyroidism that requires only hormone replacement, or psoriasis that does not require systemic treatment
- Diagnosis of immunodeficiency or treatment with systemic immunosuppressive therapy within 28 days prior to the first dose of trial treatment, including systemic corticosteroids
- High risk of bleeding or require the use of anticoagulants for management of a known bleeding diathesis
- Recipient of any live virus vaccine within 4 weeks prior to the first dose of trial treatment or any non-live vaccine within two weeks prior to the first dose of trial treatment
- History of clinically significant, medically unstable disease which, in the judgment of the Investigator, would jeopardize the safety of the participant, interfere with trial assessment or evaluation, or otherwise impact the validity of the trial results
- Fewer than two acceptable sites are available for IM injection considering the deltoid and anterolateral quadriceps muscles. Study treatment should not be given within 2 centimeters (cm) of a tattoo, keloid or hypertrophic scar. If there is implanted metal, implanted device, within the same limb the use of the deltoid muscle on the same side of the body is excluded
- Prisoners or participants who are compulsory detained (involuntary incarceration) for treatment of either a psychiatric or physical (i.e. infectious disease) illness
- Any medical or psychological or non-medical condition that might interfere with the participation or safety of the participant, as determined by the investigator
Key Trial Info
Start Date :
June 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 15 2022
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT04398433
Start Date
June 15 2020
End Date
December 15 2022
Last Update
September 19 2024
Active Locations (11)
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1
Mayo Clinic Arizona
Phoenix, Arizona, United States, 85054
2
University of California at Davis
Sacramento, California, United States, 95817
3
Winship at Emory University Hospital Midtown
Atlanta, Georgia, United States, 30308
4
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21287