Status:
COMPLETED
End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Hemodynamic Instability
General Anesthesia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of the study is to evaluate the influence of different durations of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients in the operating r...
Detailed Description
The reduction of postoperative complications is an essential aspect of care in perioperative medicine. Many studies have shown that individualized hemodynamic therapy, by optimizing fluid administrat...
Eligibility Criteria
Inclusion
- Adults (age \>18 years)
- Scheduled to undergo planned surgery under general anesthesia
- Surgery requiring invasive arterial and stroke volume monitoring
- Clinical indication to perform a fluid challenge
- Patients able to give informed consent
- Affiliated to a social security scheme
Exclusion
- Patient refusal to participate or inability to provide informed consent
- Protected major
- History of lobectomy or pneumectomy
- Patient with reduced left (ejection fraction \< 45%) or right ventricular systolic function
- Arrythmia
- Severe valvulopathy
- Body Mass Index \<15 or \> 40kg/m2
- Contraindication to insertion of invasive arterial line into radial artery
- Emergency surgery
- Pregnancy
Key Trial Info
Start Date :
August 3 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 24 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04399278
Start Date
August 3 2020
End Date
March 24 2021
Last Update
August 25 2021
Active Locations (1)
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1
CHU
Clermont-Ferrand, France