Status:
COMPLETED
Individualized Closed Loop TMS for Working Memory Enhancement
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Memory
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The study is investigating working memory brain states by using transcranial magnetic stimulation (TMS) in combination with functional magnetic resonance imaging (fMRI). The study uses a novel, indivi...
Detailed Description
Prior to any study visits, all subjects will be pre-screened through a REDCap online self-report screening REDCap. The study involves 11 study visits. The first study visit will consist of a consenti...
Eligibility Criteria
Inclusion
- 1)18-60 years old 2) Right handed 3) No psychiatric history as diagnosed by the SCID-V 4) Normal cognition 5) Capacity to give informed consent and follow study procedures 6) Sufficient command of English language to understand and respond to written as well as verbal instructions
Exclusion
- History of neurological disorder or traumatic brain injury (other than mild)
- Unable to have an MRI scan, or current or prior medical condition that could interfere with the collection or interpretation of MRI data
- Unable to receive TMS
- Implanted devices, such as an aneurysm clip or cardiac pacemaker
- History of stroke, epilepsy, or brain scarring
- Recent use of psychoactive medications, as determined by investigators
- Pregnant, nursing, or trying to become pregnant (self-attestation alone)
- Color blindness
- Otherwise determined by investigator to be unfit for study
Key Trial Info
Start Date :
November 24 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 13 2024
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT04402294
Start Date
November 24 2021
End Date
June 13 2024
Last Update
July 17 2025
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104