Status:
UNKNOWN
Tissue Perfusion During Emergency Laparotomy
Lead Sponsor:
Copenhagen University Hospital, Hvidovre
Conditions:
Emergency Laparotomy
Intestinal Obstruction
Eligibility:
All Genders
18+ years
Brief Summary
This study is investigating the effect of intraoperative Noradrenaline on cardiac preload and stroke volume, after initial fluid resuscitation, in order to assess whether there is a masked preload res...
Detailed Description
Early detection and treatment of insufficient tissue perfusion and oxygenation is the main purpose of perioperative haemodynamic monitoring and management. Hypovolemia, septicaemia, and low flow state...
Eligibility Criteria
Inclusion
- Adults (18 years or over) undergoing emergency laparotomy/laparoscopy for following abdominal pathology:
- Perforated viscus
- Intestinal obstruction
- Emergency re-operations after elective surgery owing to paralytic/obstructive ileus, anastomotic leakage
- Provided verbal and written informed consent
- Must speak and understand the Danish language
- Intraoperative indication for Norepinephrine infusion
Exclusion
- Appendectomies, cholecystectomies, negative diagnostic laparoscopies/laparotomies, herniotomies without bowel resections, sub-acute internal hernias after gastric bypass surgery, sub-acute surgery for inflammatory bowel diseases.
- Reoperation owing to fascial separation with no other abdominal pathology identified and sub-acute colorectal cancer-surgery will be excluded from the cohort. Sub-acute surgery is defined as surgery planned within 48 hours.
- Intestinal Ischemia
- intraabdominal bleeding
- Traumas, gynecological, urogenital and other vascular pathology, pregnant patients.
- Dementia and/or cognitive dysfunction (diagnosed). If the patient is not awake, alert, and oriented, times three (to person, place, and time), this also qualifies as an exclusion criterion.
Key Trial Info
Start Date :
December 25 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 30 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04403425
Start Date
December 25 2020
End Date
November 30 2022
Last Update
April 6 2022
Active Locations (1)
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1
Copenhagen University Hospital Hvidovre
Hvidovre, Denmark