Status:
UNKNOWN
Effect of Meal Timing in T2D on Hepatocytes SRIT1 and Clock Genes
Lead Sponsor:
Tel Aviv University
Conditions:
Type 2 Diabetes
Obesity
Eligibility:
All Genders
30-70 years
Phase:
NA
Brief Summary
This study is undertaken to explore in T2D, the effect of meal timing on serum induced SIRT1 and Clock Genes mRNA expression in cultured hepatocytes. Fasting serum samples were collected from T2D part...
Detailed Description
The timing of many physiological processes, including glucose metabolism, is coordinated by the circadian clock gene system. The circadian clock regulation, optimize glucose metabolism for the consump...
Eligibility Criteria
Inclusion
- T2D patients with stable treatment for at least 3 month preceding the study.
- HgA1c \>7.5 %.
- Age \> 30 years.
- BMI: 27-34 kg/m2.
- Treatment with antidiabetic drugs (i.e. metformin, DPP4 inhibitors, glinides) and GLP-1 analogs, will be allowed
- Anti-hypertensive treatment will be allowed.
- Lipid-lowering medication also allowed
Exclusion
- Type 1 diabetes.
- Major illnesses (liver, heart, kidney, infectious, neurological, psychiatric, immunological, active malignancy).
- Change in weight of \> 4.5 kg within 3 month prior the diet onset.
- Night or rotating shift workers.
- Those who crossed more than 2 time zones during 2-week period prior to study onset.
Key Trial Info
Start Date :
May 31 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 20 2020
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04405895
Start Date
May 31 2020
End Date
October 20 2020
Last Update
May 28 2020
Active Locations (1)
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1
Wolfson Medical Center
Holon, Please Select, Israel, 58100