Status:
COMPLETED
Hypoxia-Specific Imaging to Predict Outcomes of Chimeric Antigen Receptor T-cell Therapy
Lead Sponsor:
University of California, San Francisco
Conditions:
Recurrent Aggressive Non-Hodgkin Lymphoma
Recurrent Diffuse Large B-Cell Lymphoma
Eligibility:
All Genders
18+ years
Brief Summary
This study evaluates whether tumors present in patients with cancer who are planned to get CAR T-cells have low amounts of oxygen (hypoxia). PET scans may be used to check the amounts of oxygen within...
Detailed Description
PRIMARY OBJECTIVE: I. To evaluate the incidence of intratumoral hypoxia in patients with relapsed or refractory (R/R) malignancies before treatment with chimeric antigen receptor (CAR) T-cell therapy...
Eligibility Criteria
Inclusion
- Histologically confirmed diagnosis of:
- Aggressive lymphoma, including: Diffuse large B-cell lymphoma (DLBCL) (including transformed disease), high-grade B-cell lymphoma, or primary mediastinal B-cell lymphoma
- Multiple myeloma (MM), with imaging within 6 months of enrollment demonstrating \>= 1 plasmacytoma measuring \>= 5 cm along any axis
- Other malignancy with radiographically measurable disease
- R/R disease with planned receipt of CAR T-cell therapy at University of California, San Francisco (UCSF), either through an Food and Drug Administration-approved CAR construct or through a separate interventional clinical trial
- Ability to provide informed consent prior to study entry
Exclusion
- Any serious and/or unstable pre-existing medical, psychiatric, or other condition that could interfere with participant's safety, provision of informed consent, or compliance with study procedures
- Pregnancy or active lactation
Key Trial Info
Start Date :
April 16 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 9 2023
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT04409314
Start Date
April 16 2020
End Date
August 9 2023
Last Update
August 21 2023
Active Locations (1)
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1
University of California, San Francisco
San Francisco, California, United States, 94143