Status:
COMPLETED
Multi-modality Imaging & Immunophenotyping of COVID-19 Related Myocardial Injury
Lead Sponsor:
University of Cambridge
Collaborating Sponsors:
Cambridge University Hospitals NHS Foundation Trust
British Heart Foundation
Conditions:
COVID19
Cardiovascular Diseases
Eligibility:
All Genders
18-99 years
Brief Summary
Cardiovascular involvement in coronavirus disease-2019 (COVID-19) encompasses a wide range of vascular and myocardial pathologies, including both acute and long-term sequelae. The MIIC-MI study aims t...
Detailed Description
Cardiovascular involvement in coronavirus disease-2019 (COVID-19) encompasses a wide range of vascular and myocardial pathologies, including both acute and long-term sequelae. Cardiac Troponin elevat...
Eligibility Criteria
Inclusion
- Patients \>18 years old
- Confirmed COVID-19 infection AND Troponin I elevation \>99th percentile of upper reference limit OR new-onset heart failure OR unexplained cardiac symptoms
- Able to give written, informed consent
Exclusion
- Women of child-bearing potential not using adequate contraception
- Contra-indication to MRI scanning
- Contrast allergy or contrast-nephropathy
- Chronic kidney disease (eGFR \<30 mL/min/1.73 m2)
- Previous myocardial infarction
- Uncontrolled atrial fibrillation
- Uncontrolled chronic inflammatory disease
- Severe lymphopenia (\<0.2 x109/L)
- Treatment with immunomodulatory therapies within the last month (excluding inhaled or topical steroid therapy)
- Any medical condition, in the opinion of the investigator, that prevents the participant from lying flat during scanning, or from participating in the study
Key Trial Info
Start Date :
July 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2023
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT04412369
Start Date
July 1 2020
End Date
August 1 2023
Last Update
July 19 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Cambridge Univeristy Hospitals NHS Foundation Trust
Cambridge, United Kingdom, CB2 0QQ