Status:
COMPLETED
Effect of Periodontal Debridement on Leptin Levels in Obese
Lead Sponsor:
Universidad Nacional Andres Bello
Conditions:
Periodontitis
Obesity
Eligibility:
All Genders
25-70 years
Phase:
NA
Brief Summary
The main purpose of the study is to quantify of Leptin hormone in patients with normal weight, class I obesity, class II obesity and periodontitis, before and after scaling and root planning (SRP) and...
Detailed Description
Definition of the sample: 30 patients were recruited from the Diagnosis Unit of Andres Bello University Faculty of Dentistry (DUFD), campus Viña del Mar, with the diagnosis of Generalized Periodontiti...
Eligibility Criteria
Inclusion
- Patients ≥ 18 years.
- Patients classified by the American Society of Anesthesiologists (ASA) as ASA I or ASA II that are compatible with local anaesthesia procedures; - Present at least 10 natural teeth, excluding semi-erupted third molars.
- Present at least 6 sites with a probing depth (PD) ≥ 5mm and clinical attachment loss (CAL) ≥ 4mm.
- BMI between 18,50 - 39,99 kg/m2.
Exclusion
- Patients with hemostasis disorders.
- Patients who use any medication associated with gingival disorders such as: Anticonvulsants (Phenytoin), Calcium channel blockers (Nifedipine), Immunosuppressive drugs (Cyclosporins).
- Patients with systemic diseases that affect the immunoinflammatory response.
- Patients under treatment with drugs such as: warfarin, digoxin and acetylsalicylic acid.
- Previous history of allergy to local anesthetics.
- Patients who suffer from systemic conditions that can affect the progression of periodontitis and/or the gain or loss of weight, for example:
- Diabetes Mellitus, immunological disorders, hypothyroidism,etc.
- Patients who are under weight loss treatment (pharmacological, diet, exercise,etc).
- Patients presenting orthodontic appliances.
- Patients who have received antibiotic or periodontal treatment in the last 3 months.
- Pregnancy.
- Carriers of valvular prostheses or failures in heart valves, with endocarditis risk.
- Patients who are psychically and intellectually incapacitated to participate, according to the Chilean law number 20,584, title II, paragraph 8, article 28.
- Heavy smoking patients, which is smoking more than 10 cigarettes per day.
Key Trial Info
Start Date :
December 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2019
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT04417478
Start Date
December 1 2016
End Date
July 1 2019
Last Update
July 13 2020
Active Locations (1)
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1
Universidad Nacional Andres Bello
Viña del Mar, Región de Valparaíso, Chile, 2520000