Status:
COMPLETED
Bone Marrow Mesenchymal Stem Cells Transfer in Patients With ST-segment Elevation Myocardial Infarction
Lead Sponsor:
Affiliated Hospital of North Sichuan Medical College
Collaborating Sponsors:
Chinese PLA General Hospital
Peking Union Medical College Hospital
Conditions:
Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
To investigate the effect and safety of intracoronary autologous bone morrow mesenchymal stem cells (BM-MSCs) transplantation in patients with ST-segment elevation myocardial infarction（ STEMI） .
Detailed Description
To investigate the safety of intra-coronary injection of autologous bone marrow mesenchymal stem cells (BM-MSCs) in patients with ST-segment elevation myocardial infarction and its effect on cardiac f...
Eligibility Criteria
Inclusion
- Age\> 18 years old;
- Diagnosed acute ST-elevation myocardial infarction (STEMI)
- STEMI onset \<1 month
- Successful vascular remodeling, blood flow of infarct-related blood vessels recovered to TIMI level 3
- All patients included in the study signed an informed consent form and promised to complete all follow-up plans
Exclusion
- Refractory persistent ventricular tachycardia
- High cardiac block and no pacemaker control
- Liver or renal dysfunction (ALT\>80U/ L, Cr\> 440mmol / L)
- Bleeding disorders, malignant tumors
- Autoimmune disease or any serious fatal disease
- Contraindications for coronary intervention
- Combined with other heart disease: congenital heart Disease (ventricular deficiency, atrial deficient, patent ductus arteriosus and other congenital alformations),primary valvular disease, active myocarditis, pulmonary heart disease,hyperthyroidism, mucous edema heart disease and so on
- Mental illness, no self-awareness, and no precise expression and cooperation
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 15 2011
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT04421274
Start Date
May 1 2008
End Date
July 15 2011
Last Update
June 9 2020
Active Locations (1)
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1
The Third Hospital of Mianyang
Mianyang, Sichuan, China, 0816