Status:
COMPLETED
Preventing Bed-rest Induced Muscle Loss in the Elderly
Lead Sponsor:
University of Birmingham
Collaborating Sponsors:
Biotechnology and Biological Sciences Research Council
University of Nottingham
Conditions:
Muscle Loss
Disuse Atrophy
Eligibility:
MALE
65-80 years
Phase:
NA
Brief Summary
Episodes of inactivity due to hospitalisation, as short as 5 days, are associated with rapid muscle and strength loss in the elderly. The observed muscle loss with inactivity is likely due to muscle a...
Detailed Description
Participants will be assigned to either single-bout (SINGLE; n=10) or multiple-bouts (MULTI; n=10) of resistance exercise prehabilitation prior to 5 consecutive days of bed rest. Groups will be matche...
Eligibility Criteria
Inclusion
- Males aged between 65-80 years
- No history of structured resistance training within 10 years prior to study participation.
- Generally good health as indicated by a thorough health questionnaire.
- A score of ≥9 points on the Short Physical Performance Battery to assess lower extremity function.
- Body Mass Index \<30kg/m2
Exclusion
- Coagulation disorders
- Myocardial infarction
- Artery/vein disease
- Hormone replacement therapy
- Other chronic/systemic illnesses (i.e. renal failure, chronic obstructive pulmonary disease, cancer).
- Undergone 2 or more muscle biopsies from each leg previously.
- Received a stable isotope infusion in the last 3 years prior to study enrollment.
Key Trial Info
Start Date :
September 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04422665
Start Date
September 1 2017
End Date
January 1 2020
Last Update
June 9 2020
Active Locations (1)
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1
University of Birmingham, School of Sport, Exercise and Rehabilitation Sciences
Edgbaston, West Midlands, United Kingdom, B15 2TT