Status:
COMPLETED
Myocardial Strain Analysis in Anaesthetized Coronary Artery Disease Patients During Hyperoxia and Normoxaemia
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Conditions:
Coronary Artery Disease
Anesthesia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients with coronary artery disease.
Detailed Description
Up to 106 patients with coronary artery disease undergoing elective coronary artery bypass graft (CABG) surgery will be recruited to undergo this single visit study. In the timeframe shortly after the...
Eligibility Criteria
Inclusion
- Elective CABG surgery (with or without other cardiac surgery)
- Ability to give and sign informed consent
- Age \>18 years.
Exclusion
- Absolute contraindication for TEE
- Emergency surgery, including but not limited to patients with instable CAD: ST- and Non-ST-elevation myocardial infarction (STEMI, NSTEMI) and instable angina (instable AP)
- Atrial fibrillation or significant arrhythmia
- Pacemaker, CRT, left bundle branch block
- Severe-grade valvular disease
- Pericardial disease
- Previous cardiac or thoracic aortic surgery
- Previous chest radiation therapy or cardiotoxic or bleomycin chemotherapy
- Severe pulmonary hypertension, cor-pulmonale, or right ventricular dysfunction, i.e., where high FIO2 might reduce pulmonary vascular resistance and right ventricular afterload
- Patients where study explanation and informed consent cannot been performed/obtained at the latest on the day before scheduled surgery
- Females of child-bearing potential
Key Trial Info
Start Date :
June 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 4 2021
Estimated Enrollment :
106 Patients enrolled
Trial Details
Trial ID
NCT04424433
Start Date
June 1 2020
End Date
June 4 2021
Last Update
June 9 2021
Active Locations (1)
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1
Bern University Hospital, Inselspital
Bern, Switzerland, 3010