Status:
COMPLETED
Preemptive Oral Gabapentin 600 mg in Reducing Morphine Requirement After Non Obstetric Lower Abdominal Surgery
Lead Sponsor:
Indonesia University
Conditions:
Non-obstetric Lower Abdominal Surgery
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
PHASE2
Brief Summary
This study aimed to get the information about the effectiveness of preemptive oral gabapentin 600 mg in reducing morphine requirement after non obstetric lower abdominal surgery
Detailed Description
Seventy-two subjects were given informed consent before enrolling the study and randomized into two groups; gabapentin and placebo. Two hours before the incision, patients were given preemptive analge...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Male or female
- Age: 18-65 years old
- Weigh in range around 20% of the ideal body weight
- Physical status ASA I-II
- Scheduled for elective non-obstetric lower abdominal surgery with general anesthesia
- Duration of surgery less than 4 hours
- Patients who agreed to participate in this study and sign informed consent
- Exclusion criteria:
- Patients who have history of allergy or hypersensitivity to gabapentin, paracetamol, morphine, or the other opioids
- Patients who consumed analgesia and NSAID less than 12 hours before surgery
- Patients who experienced physical trauma less than 4 days before surgery
- Patients who have contraindications to gabapentin, morphine, and paracetamol
- Patients who were treated with neuraxial block or peripheral nerve block before and during surgery
- Patients who have history of diabetes, severe live or renal disease
- Patients who were treated with antihypertension, sedatives, hypnotics, antidepressants, and the other drugs that have effects on nervous system
- Patients who have psychiatric disorders
- Patients who consumed gabapentin before perioperative period
- Pregnant or breastfeeding patients
Exclusion
Key Trial Info
Start Date :
November 11 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 29 2020
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT04434430
Start Date
November 11 2019
End Date
February 29 2020
Last Update
September 13 2021
Active Locations (1)
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1
Cipto Mangunkusumo Cental National Hospital
Jakarta, DKI Jakarta, Indonesia, 10430