Status:
WITHDRAWN
The Utility of Camostat Mesylate in Patients With COVID-19 Associated Coagulopathy (CAC) and Cardiovascular Complications
Lead Sponsor:
Yale University
Collaborating Sponsors:
Ono Pharmaceutical Co. Ltd
Conditions:
Coagulopathy
Cardiovascular Complication
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
The primary aim of this study is to determine whether Camostat mesylate reduces SARS-COV-2 associated coagulopathy. Additional aims are to determine the effect of Camostat mesylate on SARS-COV-2 assoc...
Detailed Description
The trial is in-patient only. Participants are identified by the hospital physicians and house staff, and contacted by research study personnel. Potential participants fulfilling inclusion criteria an...
Eligibility Criteria
Inclusion
- . Positive COVID-19 test result.
- Diagnosis of COVID-19 associated coagulopathy and cardiac complications based on D-Dimer, fibrinogen, TnT, CTPE, ischemic EKG changes
- Provision of informed consent. In patients with altered mental status consents can be obtained from the power of attorney.
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Male or female, age 18 or older
- Diagnosed with hypoxia requiring intubation or positive air pressure.
- Diagnose with DVT/PE by ultrasound and CTPE and/or
- Elevated D-Dimer and/or
- Greater than 2-fold increase in TnT
- Ischemic EKG changes with ST depression or elevation more than 1 mm in 2 consecutive leads
- Ability to administer oral medication.
Exclusion
- GFR\<30 mL/min
- Severe bleeding requiring blood transfusion of drop of 5% in HCT.
- Pregnancy or lactation
- Known allergic reactions to components of Camostat mesylate.
- Subjects under age 18
Key Trial Info
Start Date :
November 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2021
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04435015
Start Date
November 1 2021
End Date
December 31 2021
Last Update
May 18 2022
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.