Status:
RECRUITING
Antibiotic Dosing in Geriatric Patients At the Emergency Department
Lead Sponsor:
University Hospital, Ghent
Conditions:
Elderly Infection
Frailty
Eligibility:
All Genders
75+ years
Brief Summary
In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Am...
Detailed Description
In drug research studies, older people - and especially patients with a geriatric profile or frailty risk - are very frequently excluded. Moreover, drug dosing is often extrapolated from studies in yo...
Eligibility Criteria
Inclusion
- Patients presenting at the emergency department and later on admitted to the geriatric department
- Patient age 75 years or older
- Patients with geriatric profile according to KATZ scale, G8 screening test or CIRS score.
- Patient receiving antibiotic treatment (amoxicillin-clavulanate, piperacillin-tazobactam)
- Intravenous access available for blood sampling. For measurement of the peak concentration an intravenous access other than the drug infusion line is required.
Exclusion
- Admission to other units than the geriatric department incl. the ICU.
- Absence of informed consent
- Known hypersensitivity to beta-lactam antibiotics
- Patients who received oral amoxicillin-clavulanate prior to admission will not be included in the iv. amoxicillin-clavulanate group.
Key Trial Info
Start Date :
January 3 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2025
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT04436991
Start Date
January 3 2018
End Date
January 1 2025
Last Update
September 19 2024
Active Locations (1)
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1
University Hospital Ghent
Ghent, Belgium, 9000