Status:
ACTIVE_NOT_RECRUITING
Renal Metabolism of Glycolate to Oxalate
Lead Sponsor:
University of Alabama at Birmingham
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Healthy
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This study will determine the contribution of glycolate metabolism to urinary oxalate excretion in healthy subjects, using carbon 13 isotope glycolate tracer technique and a low-oxalate controlled die...
Detailed Description
It is known that glycolate, an intermediary molecule in normal metabolism, can be converted into oxalate. The origin of urinary oxalate is of interest as calcium oxalate is a main component of kidney ...
Eligibility Criteria
Inclusion
- Mentally competent adults, able to read and comprehend the consent form
- 18-75 years of age
- Body Mass Index (BMI) between 19 and 40
- In good health as judged from a medical history, reported medications, and a complete blood metabolic profile
- Acceptable 24 hour urine collections (performed twice for screening)
Exclusion
- History of any hepatic, renal, bowel, or endocrine disease or any other condition that may influence the absorption, transport or urine excretion of ions
- Abnormal urine chemistries or blood metabolic profiles
- Poor 24 hour urine collections completed during screening, judged by 24 hour urine creatinine excretion (indicative of not collecting all urine in the 24 hour period)
- Pregnancy, intention to become pregnant in the near future, or lactation
- Aged \<18 or \>75
- BMI \<19 or \>40
Key Trial Info
Start Date :
March 12 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT04437225
Start Date
March 12 2020
End Date
September 1 2027
Last Update
December 19 2025
Active Locations (1)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233