Status:
RECRUITING
Cisplatin Induced Kidney Toxicity
Lead Sponsor:
The Hospital for Sick Children
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
London Health Sciences Centre
Conditions:
Acute Kidney Injury
Cancer
Eligibility:
All Genders
3+ years
Brief Summary
Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known toxicity, CisP is still widely used as a f...
Eligibility Criteria
Inclusion
- Adult participants: Initiating treatment with CisP (≥75 mg/m2) for head/neck or lung cancers at one of the Adult participating sites; 18 years of age or older.
- Paediatric participants: Initiating treatment with CisP for any cancer diagnosis at one of the Pediatric participating sites; greater than 3 months of age.
- All participants: Consent to participate in the study.
Exclusion
- Diagnosis of chronic kidney disease (CKD) at baseline (glomerular filtration rate \<60 mL/min/1.73m2, determined by chart review of either formal glomerular filtration rate testing, 24 hour creatinine creatinine clearance of age-appropriate serum creatinine-based estimated glomerular filtration rate equations; past kidney transplant)
- Previous use of any nephrotoxic drugs included on the provided Excluded Nephrotoxic Medications list in the two weeks prior to initiation of CisP treatment
- Previous use of CisP
- Previous radiotherapy (total body irradiation or abdominal radiation only) in the last 1 month prior to study
- Previous hematopoietic stem cell transplant
- Any chronic or acute health condition that the investigator feels would render the patient inappropriate for this study, including but not limited to significant uncontrolled cardiorespiratory, hepatic, infectious, or renal disease at the discretion of the investigator
Key Trial Info
Start Date :
August 12 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT04442516
Start Date
August 12 2020
End Date
December 31 2028
Last Update
April 17 2024
Active Locations (1)
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1
London Health Sciences Centre
London, Ontario, Canada, N6A 5W9