Status:
UNKNOWN
The Synergistic Effects of Intra-articular Hyaluronic Acid and Platelet-rich Plasma Injections on Knee Osteoarthritis
Lead Sponsor:
Taipei Medical University WanFang Hospital
Conditions:
Osteoarthritis Knees Both
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
Although intra-articular knee injection with platelet-rich plasma (PRP) may have better outcomes than using hyaluronic acid (HA) for people with knee osteoarthritis (OA), it is expensive to use PRP. P...
Detailed Description
People aged \>65 years are over 14% in Taiwan since the year 2018. Knee osteoarthritis (OA) is prevalent among elderly people. People with knee OA often have knee pain and stiffness as well as comprom...
Eligibility Criteria
Inclusion
- The study will recruit persons aged between 50 and 80 years who have experienced symptomatic knee OA for 6 months or more. They have a radiographic picture of knee OA of grades 1-3, based on the Kellegren-Lawrence scale.
Exclusion
- Those who have diabetes, fever, anemia (Hb \<10 g/dl), thrombocytopenia (platelet count \<150000/ml), a blood-clotting disease, knee deformity (genu valgum/varum \>20 degrees), impaired leg mobility secondary to neuromuscular diseases or a bony fracture, impaired mental function who have difficulty in completing outcome assessments, severe cardiopulmonary impairment, taking anticoagulants long-term, a history of intra-articular steroid injection in the prior 1 year, a history of knee injury involving ligaments and menisci, and a history of malignancy are excluded.
Key Trial Info
Start Date :
June 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04443166
Start Date
June 1 2020
End Date
June 1 2022
Last Update
June 23 2020
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