Status:
NOT_YET_RECRUITING
EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients
Lead Sponsor:
Columbia University
Conditions:
Postoperative Delirium
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
The investigators intend to recruit 600 participants to see if alpha power during anesthesia is influenced by analgesic medication and associated with a reduction of delirium following surgery.
Detailed Description
Postoperative delirium may manifest in the immediate post-anesthesia care period. Such episodes appear to be predictive of further episodes of inpatient delirium and associated adverse outcomes. Intra...
Eligibility Criteria
Inclusion
- Adults aged 60 years or over
- Has capacity to provide informed consent
- Undergoing elective non-cardiac surgery, which does not involve the head or neck, with planned volatile-based general anesthesia of expected duration of at least 2 hours
Exclusion
- Chronic pain with opioid requirement or concurrent use of enzyme inducers, e.g. carbamazepine, phenytoin,
- Illicit substance use or excessive alcohol intake
- Refusal by patient or case anesthesiologist responsible for patient's care
Key Trial Info
Start Date :
April 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2031
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT04443517
Start Date
April 1 2026
End Date
March 31 2031
Last Update
January 7 2026
Active Locations (1)
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1
Columbia University Irving Medical Center
New York, New York, United States, 10032