Status:
UNKNOWN
Efficacy and Safety of Anti HCV Drugs in the Treatment of COVID-19
Lead Sponsor:
Cairo University
Conditions:
COVID-19
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
PHASE3
Brief Summary
COVID 19 which started from a zoonotic transmission related to crowded markets was confirmed to have a high potential for transmission to close contacts on 20 January 2020 by the National Health Commi...
Detailed Description
In December, 2019, an outbreak of pneumonia with unknown cause occurred in Wuhan city, the capital of Hubei province in China. On January 7th, the scientists succeeded to isolate a novel coronavirus, ...
Eligibility Criteria
Inclusion
- positive reverse-transcriptase-polymerase chain- reaction (RT-PCR) assay for SARS- CoV-2 in a respiratory tract sample
Exclusion
- ● Known allergy or hypersensitivity to the used medications
- Known severe liver disease (e.g., cirrhosis, with an alanine aminotransferase level \>5× the upper limit of the normal range or an aspartate aminotransferase level \>5× the upper limit of the normal range)
- Use of medications that are contraindicated with the trial medications and that could not be replaced or stopped during the trial period
- Pregnancy or breast-feeding or known active HCV infection, because of concerns about the development of resistance
- History of bone marrow transplant
- Known G6PD deficiency
- Chronic hemodialysis or Glomerular Filtration Rate \< 20ml/min
- Psoriasis
- Porphyria
- Concomitant use of digitalis, flecainide, amiodarone, procainamide, or propafenone
- Known history of long QT syndrome
- Current known QTc\>500 msec
- Pregnant or nursing
- Weight \< 35kg
- Seizure disorder
- Patients receiving Amiodarone.
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04443725
Start Date
July 1 2020
End Date
December 1 2020
Last Update
June 25 2020
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