Status:
RECRUITING
Prognostic Factors to Regain Consciousness
Lead Sponsor:
BDH-Klinik Hessisch Oldendorf
Conditions:
Neurologic Disorder
Disorder of Consciousness
Eligibility:
All Genders
18-85 years
Brief Summary
The study aims to identify factors that predict the medium and long-term outcome of patients with disorders of consciousness (DOC) undergoing early neurological rehabilitation. In this prospective, o...
Detailed Description
Due to continuous improvements in acute medical care, the number of patients surviving severe brain damage has increased over the past decades. While some patients improve significantly during the fir...
Eligibility Criteria
Inclusion
- early neurological rehabilitation (phase B)
- stroke, traumatic brain injury, hypoxic-ischemic encephalopathy
- disorder of consciousness (coma, UWS, MCS)
- at minimum two weeks after disease onset
- admission to intensive care unit
- written consent from the patient's legal representative
- exclusion of pregnancy
Exclusion
- insufficient cardiorespiratory stability
- fractures or severe infratentorial brain injuries leading to impaired auditory evoked - potentials
- previous brain damage
- mental disorders (dementia, depression)
- colonization with multi-resistant pathogens
- MRI contraindications
- claustrophobia
- weight \> 120 kg
Key Trial Info
Start Date :
June 15 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 15 2027
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT04445649
Start Date
June 15 2020
End Date
December 15 2027
Last Update
September 19 2025
Active Locations (1)
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1
BDH-Clinic Hessisch Oldendorf
Hessisch Oldendorf, Germany, 31840