Status:
COMPLETED
COVID-19: Longitudinal Study of Seroprevalence of SARS-CoV-2 Antibodies and Development of Immunity in School Children
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Swiss School of Public Health (SSPH+)
Conditions:
SARS-CoV 2
COVID-19
Eligibility:
All Genders
5+ years
Brief Summary
There is a lack of knowledge about how many children are infected with SARS-CoV-2, how often they are asymptomatic, and how long the immunity persists. The main purpose of this study is to measure an...
Detailed Description
The role of children and adolescents in the transmission of SARS-CoV-2 remains highly unclear and has been a key question since the early days of the pandemic. It has important consequences for policy...
Eligibility Criteria
Inclusion
- Any school child residing in Switzerland aged 5 years or older and attending a consenting to participate public or private school that hosts classes of interest (grade 1 through 9) in the canton of Zürich.
- Parents of participating children.
- Personnel employed in the participating schools.
- No acute respiratory and SARS-CoV-2 infection:
- In case of unknown respiratory infection, no presence of symptoms for at least 48 hours.
- In case of confirmed SARS-CoV-2 infection: inclusion at the earliest 21 days from PCR-positive diagnosis after the onset of potential symptoms and no presence of symptoms for at least 48 hours (according to Standard of Care).
- Informed consent of parents or legal guardians and children, or the adult participant.
Exclusion
- No informed consent by schools or children, or the adult participant.
- Schools with \<40 students in one of the sampled grades (1, 2, 4, 5, 7, or 8).
- Children of Kindergarten age and younger.
- Suspicion of acute COVID-19 infection.
- Special need schools.
Key Trial Info
Start Date :
June 16 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 20 2022
Estimated Enrollment :
4250 Patients enrolled
Trial Details
Trial ID
NCT04448717
Start Date
June 16 2020
End Date
July 20 2022
Last Update
April 3 2025
Active Locations (1)
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1
Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich
Zurich, Switzerland, 8001