Status:
COMPLETED
A Phase 2 Study of LY3209590 in Participants With Type 2 Diabetes Mellitus
Lead Sponsor:
Eli Lilly and Company
Conditions:
Type 2 Diabetes Mellitus
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
The reason for this study is to see if the study drug LY3209590 is safe and effective in participants with type 2 diabetes.
Eligibility Criteria
Inclusion
- Participants must have type 2 diabetes mellitus according to the World Health Organization (WHO) criteria treated with a stable dose of metformin in combination with a stable dose of Dipeptidyl Peptidase IV (DPPIV) inhibitor and/or a Sodium-glucose co-transporter-2 (SGLT2) inhibitor for at least 3 months prior to screening
- Participants must have a HbA1c value of 7.0% to 9.5%, inclusive
- Participants must have a body mass index (BMI) between 20 and 45 kilograms per meter squared (kg/m²), inclusive
Exclusion
- Have type 1 diabetes mellitus or latent autoimmune diabetes
- Have any episodes of severe hypoglycemia and/or hypoglycemia unawareness within the 6 months prior to screening
- Have any of the following cardiovascular (CV) conditions: acute myocardial infarction, New York Heart Association Class III or IV heart failure, or cerebrovascular accident (stroke)
- Have acute or chronic hepatitis, or obvious clinical signs or symptoms of any other liver disease
- Have an estimated glomerular filtration rate (eGFR) \<30 milliliters/minute/1.73 m²
- Have active or untreated cancer
- Are receiving chronic (\>14 days) systemic glucocorticoid therapy
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 8 2021
Estimated Enrollment :
278 Patients enrolled
Trial Details
Trial ID
NCT04450394
Start Date
July 1 2020
End Date
October 8 2021
Last Update
November 2 2022
Active Locations (64)
Enter a location and click search to find clinical trials sorted by distance.
1
Syed Research Consultants Llc
Sheffield, Alabama, United States, 35660
2
National Research Institute - Huntington Park
Huntington Park, California, United States, 90255
3
National Research Institute - Wilshire
Los Angeles, California, United States, 90057
4
Catalina Research Institute, LLC
Montclair, California, United States, 91763